Brownie and its successor Ape are Python frameworks that support both Solidity and Vyper projects, letting you write pytest-style tests, manage deployments, and fork mainnet state for integration tests.
def test_transfer(token, accounts):
token.transfer(accounts[1], 100, {"from": accounts[0]})
assert token.balanceOf(accounts[1]) == 100Mainnet forking is especially valuable for Vyper DeFi contracts: you can test real interactions against deployed protocols (like an actual Uniswap pool) without spending real ETH.